Hepatic lipogenesis and its abnormalities
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چکیده
منابع مشابه
Fatty acid metabolism and hepatic lipogenesis.
The conversion of octanoate-l-Cl4 to radioacetoacetate and the effect of pyruvate on this process are dependent on the K+ concentration in the incubation medium (1). These results prompted this investigation in which the incorporation of octanoate-l-Cl4 into fatty acids and cholesterol was determined in the presence of non-radioactive additions of pyruvate, succinate, and fumarate. Malonate was...
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Needle biopsies of the liver were performed on 30 patients with heart failure and correlated with clinical features and biochemical liver function studies. Hepatic biopsy served as a useful adjunct to other methods in deciding the status of the liver in this group. Type of heart disease, degree of heart failure and length of heart failure could not be correlated with the observed histology. Nei...
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Estrogens have been shown to protect against various diseases and disastrous metabolic consequences of poor diets. Although a large body of research demonstrates estrogen's ability to control food intake, adipogenesis, and oxidative stress, research regarding the effects of estrogens on hepatic lipogenesis, steatosis, and non-alcoholic fatty liver disease is only now accumulating. Estrogen defi...
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The hyperlipidemia accompanying infection has been attributed to production of tumor necrosis factor. This cytokine inhibits adipose tissue lipoprotein lipase, which could decrease clearance of lipoproteins. Infections also increase hepatic lipogenesis. We now have demonstrated that tumor necrosis factor-alpha stimulates lipid synthesis in vivo. 2 h after administration of tumor necrosis factor...
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Hepatic steatosis is associated with detrimental metabolic phenotypes including enhanced risk for diabetes. Stearoyl-CoA desaturases (SCDs) catalyze the synthesis of MUFAs. In mice, genetic ablation of SCDs reduces hepatic de novo lipogenesis (DNL) and protects against diet-induced hepatic steatosis and adiposity. To understand the mechanism by which hepatic MUFA production influences adipose t...
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ژورنال
عنوان ژورنال: Kanzo
سال: 1975
ISSN: 0451-4203,1881-3593
DOI: 10.2957/kanzo.16.487